A Type E plug in Sao Tome and Principe?
Yes — it seats, earth and all.
Sao Tome and Principe's Type F and Type C sockets accept a Type E plug (French). Both sides carry an earth, so grounded appliances keep their protection. The wall delivers 220 V at 50 Hz (198–242 V within tolerance) — if your device isn't rated for that (look for "100–240 V" on the brick), an adapter won't save it.
Grid facts verified against IEC World Plugs — Sao Tome and Principe. Physical-fit verdicts derive from pin geometry and each socket standard's acceptance list — not safety advice.